Peptide Information

General Information of This Peptide
Peptide ID
BTDP008506
Peptide Name
Potassium channel toxin alpha-KTx 4.8
Symonym
Cm39
Species
Centruroides margaritatus (Central American bark Scorpion)
Uniprot Name
KAX48_CENMA
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
TFINHKCKSSSECLPACKAAIGRASGKCINSTCKCYY
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Sequence Length
37
Mass (Da)
3988
Sequence Removed Signal Peptide
TFINHKCKSSSECLPACKAAIGRASGKCINSTCKCYY
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Disulfide Bond
13-33;17-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides margaritatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Dissociation constant
58 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 Dissociation constant
59 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
65 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
65 nM
 .
Blocker
 [1]
 Target Info    KCa2.2 Dissociation constant
502 nM
 .
Blocker
 [1]
 Target Info    KCa2.2 Dissociation constant
575 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
1 μM
Blocker
 [1]
References
Ref 1 Characterization and Chemical Synthesis of Cm39 (-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1. Toxins (Basel). 2023 Jan 5;15(1):41. doi: 10.3390/toxins15010041.
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