Peptide Information

General Information of This Peptide
Peptide ID
BTDP008500
Peptide Name
Potassium channel toxin alpha-KTx 4.1
Symonym
TSK4; Tityustoxin K-alpha; Tityustoxin-7; Toxin II-9
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KAX41_TITSE
Alphafold ID
P46114
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1HP2
Sequence
MKAFYGILIIFILISMIDLSKQVFINAKCRGSPECLPKCKEAIGKAAGKCMNGKCKCYP
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Sequence Length
59
Mass (Da)
6488
Signal Sequence
MKAFYGILIIFILISMIDLSKQ
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Sequence Removed Signal Peptide
VFINAKCRGSPECLPKCKEAIGKAAGKCMNGKCKCYP
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Disulfide Bond
29-50;35-55;39-57
PDB ID
1HP2
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Dissociation constant
0.2 nM
 .
Blocker
 [7- 18]
 Target Info    Kv1.2 Inhibition constant
0.5 nM
 .
Blocker
 [1- 6]
 Target Info    Kv1.2 Inhibition constant
1.1 nM
 .
Blocker
 [1- 6]
 Target Info    Kv7.2 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [1- 6]
 Target Info    Kv1 Inhibition rate .
100 nM
Blocker
 [19]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv11 Inhibition rate .
5 μM
Blocker
 [5]
 Target Info    Kv7.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv1.3 Inhibition rate
85 %
1 μM
Blocker
 [3]
 Target Info    Kv1 Inhibition rate
85 %
1 μM
Blocker
 [3]
 Target Info    Kv1.6 Inhibition rate
94 %
1 μM
Blocker
 [3]
 Target Info    Shaker Inhibition rate
97 %
1 μM
Blocker
 [3]
 Target Info    Kv1.2-1.2-1.2-1.2 IC50
2.6 nM
 .
Blocker
 [1- 6]
 Target Info    Kv1.2 IC50
11 nM
 .
Blocker
 [1- 6]
 Target Info    Kv1.2 IC50
12 nM
 .
Blocker
 [1- 6]
 Target Info    Kv1.2 IC50
14 nM
 .
Blocker
 [1- 6]
 Target Info    Kv1.2 IC50
15 nM
 .
Blocker
 [1- 6]
 Target Info    Kv1.2 IC50
17 nM
 .
Blocker
 [1- 6]
References
Ref 1 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 2 Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes. Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1475-9. doi: 10.1073/pnas.91.4.1475.
Ref 3 Electrophysiological characterization of Ts6 and Ts7, K? channel toxins isolated through an improved Tityus serrulatus venom purification procedure. Toxins (Basel). 2014 Feb 28;6(3):892-913. doi: 10.3390/toxins6030892.
Ref 4 Tityustoxin-K(alpha) blockade of the voltage-gated potassium channel Kv1.3. Br J Pharmacol. 2003 Jul;139(6):1180-6. doi: 10.1038/sj.bjp.0705343.
Ref 5 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
Ref 6 Interaction of a toxin from the scorpion Tityus serrulatus with a cloned K+ channel from squid (sqKv1A). Biochemistry. 2001 May 22;40(20):5942-53. doi: 10.1021/bi010173g.
Ref 7 Synthesis of Novel cis-2-Azetidinones from imines and aclychloride using triethylamine. Acta Chim Slov. 2023 Dec 4;70(4):628-633. doi: 10.17344/acsi.2023.8451.
Ref 8 Backward-Eulerian Footprint Modelling Based on the Adjoint Equation for Atmospheric and Urban-Terrain Dispersion. Boundary Layer Meteorol. 2023;188(1):159-183. doi: 10.1007/s10546-023-00807-z. Epub 2023 Apr 17.
Ref 9 Leaf spot on Alocasia macrorrhizos caused by Fusarium asiaticum in Sichuan, China. Plant Dis. 2022 Sep 11. doi: 10.1094/PDIS-04-22-0844-PDN. Online ahead of print.
Ref 10 Incidence and predictors of chronic kidney disease in type-II diabetes mellitus patients attending at the Amhara region referral hospitals, Ethiopia: A follow-up study. PLoS One. 2022 Jan 26;17(1):e0263138. doi: 10.1371/journal.pone.0263138. eCollection 2022.
Ref 11 A Method for More Accurate Determination of Resonance Frequency of the Cardiovascular System, and Evaluation of a Program to Perform It. Appl Psychophysiol Biofeedback. 2022 Mar;47(1):17-26. doi: 10.1007/s10484-021-09524-0. Epub 2021 Oct 16.
Ref 12 First Report of Fusarium wilt of Coleus forskohlii Caused by Fusarium oxysporum in China. Plant Dis. 2021 Jan 26. doi: 10.1094/PDIS-11-20-2489-PDN. Online ahead of print.
Ref 13 Shock waves from the inhomogeneous Boltzmann equation. Phys Rev E. 2019 Dec;100(6-1):062120. doi: 10.1103/PhysRevE.100.062120.
Ref 14 Classifying Changes to Preventive Interventions: Applying Adaptation Taxonomies. J Prim Prev. 2019 Feb;40(1):89-109. doi: 10.1007/s10935-018-00531-2.
Ref 15 Quantification of the passive and active biaxial mechanical behaviour and microstructural organization of rat thoracic ducts. J R Soc Interface. 2015 Jul 6;12(108):20150280. doi: 10.1098/rsif.2015.0280.
Ref 16 A model of mechanical interactions between heart and lungs. Philos Trans A Math Phys Eng Sci. 2009 Dec 13;367(1908):4741-57. doi: 10.1098/rsta.2009.0137.
Ref 17 Experimental test of nonlocal realistic theories without the rotational symmetry assumption. Phys Rev Lett. 2007 Nov 23;99(21):210406. doi: 10.1103/PhysRevLett.99.210406. Epub 2007 Nov 21.
Ref 18 Structures and phase transitions of the A7PSe6 (A = ag, Cu) argyrodite-type ionic conductors. III. alpha-Cu7PSe6. Acta Crystallogr B. 2000 Dec;56 (Pt 6):972-9. doi: 10.1107/s0108768100010260.
Ref 19 Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol. 2010 Sep;136(3):273-82. doi: 10.1085/jgp.200910398.
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