Peptide Information

General Information of This Peptide
Peptide ID
BTDP008474
Peptide Name
Potassium channel toxin alpha-KTx 19.2
Symonym
Toxin Kbot21
Species
Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Uniprot Name
KA192_BUTOC
Alphafold ID
C0HJQ2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: C0HJQ2
Sequence
AACYSSDCRVKCRAMGFSSGKCIDSKCKCYK
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Sequence Length
31
Mass (Da)
3400
Sequence Removed Signal Peptide
AACYSSDCRVKCRAMGFSSGKCIDSKCKCYK
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Disulfide Bond
3-22;8-27;12-29
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Buthus
Species: Buthus occitanus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
65 %
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
100 %
1 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
100 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
100 %
1 μM
Blocker
 [1]
 Target Info    Kv1.6 IC50
75.9 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
75.9 nM
 .
Blocker
 [1]
References
Ref 1 Characterization of Kbot21 Reveals Novel Side Chain Interactions of Scorpion Toxins Inhibiting Voltage-Gated Potassium Channels. PLoS One. 2015 Sep 23;10(9):e0137611. doi: 10.1371/journal.pone.0137611. eCollection 2015.
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