Peptide Information

General Information of This Peptide
Peptide ID
BTDP008440
Peptide Name
PI-stichotoxin-Hcr2f
Symonym
Kunitz-type serine protease inhibitor HCRG1
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
VKT2F_HETCR
Alphafold ID
C0HJU6
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HJU6
Sequence
RGICSEPKVVGPCKAGLRRFYYDSETGECKPFIYGGCKGNKNNFETLHACRGICRA
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Sequence Length
56
Mass (Da)
6202
Sequence Removed Signal Peptide
RGICSEPKVVGPCKAGLRRFYYDSETGECKPFIYGGCKGNKNNFETLHACRGICRA
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Disulfide Bond
4-54;13-37;29-50
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    chymotrypsin Inhibition constant
1.8 nM
 .
Blocker
 [1], [2], [3]
 Target Info    trypsin Inhibition constant
28 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv1.3 IC50
40.7 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
40.7 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1 IC50
142.5 nM
 .
Blocker
 [2]
 Target Info    Kv1 IC50
142.6 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.6 IC50
154.9 nM
 .
Blocker
 [2]
 Target Info    Kv1.6 IC50
154.9 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Shaker IR potassium channel IC50
433.1 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Shaker-IR IC50
433.1 nM
 .
Blocker
 [2]
 Target Info    Kv1.2 IC50
52 μM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.2 IC50
52.199 μM
 .
Blocker
 [2]
References
Ref 1 New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa. Mar Drugs. 2015 Sep 24;13(10):6038-63. doi: 10.3390/md13106038.
Ref 2 Kunitz-Type Peptides from the Sea Anemone Heteractis crispa Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities. Biomedicines. 2020 Nov 4;8(11):473. doi: 10.3390/biomedicines8110473.
Ref 3 Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model. Biomedicines. 2021 Mar 10;9(3):283. doi: 10.3390/biomedicines9030283.
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