Target Information

General Information of This Target
Target ID
BTDT00236
Target Name
Vasopressin V2 receptor (AVPR2)
Target Bioclass
Transporter and channel
Uniprot ID
P30518
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
AVPR2
Gene ID
554
Synonym
ADHR;?DIR;?DIR3; V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
Sequence
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS

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Family
the G-protein coupled receptor 1 family.
Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.

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Taxonomy ID
9606
TCDB ID
9.A.14.10.3
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mambaquaretin-7 Inhibition constant
3.14 nM
 [1], [2]
 Toxin Info    Mambaquaretin-5 Inhibition constant
3.5 nM
 [2]
 Toxin Info    Mambaquaretin-1 Inhibition constant
5.02 nM
 [2], [3], [4]
 Toxin Info    Mambaquaretin-4 Inhibition constant
7.34 nM
 [2]
 Toxin Info    Mambaquaretin-2 Inhibition constant
8.16 nM
 [2]
 Toxin Info    Mambaquaretin-3 Inhibition constant
13.3 nM
 [2]
 Toxin Info    Mambaquaretin-6 Inhibition constant
21.5 nM
 [2]
 Toxin Info    Mambaquaretin-9 Inhibition constant
45.1 nM
 [2]
 Toxin Info    Kunitz-type serine protease inhibitor NACI Inhibition constant
112 nM
 [2- 7]
References
Ref 1 The amino acid sequence of a weak trypsin inhibitor B from Dendroaspis Polylepis polylepis (black mamba) venom. Hoppe Seylers Z Physiol Chem. 1981 Oct;362(10):1377-84. doi: 10.1515/bchm2.1981.362.2.1377.
Ref 2 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28.
Ref 3 Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7154-7159. doi: 10.1073/pnas.1620454114. Epub 2017 Jun 19.
Ref 4 A snake toxin as a theranostic agent for the type 2 vasopressin receptor. Theranostics. 2020 Sep 18;10(25):11580-11594. doi: 10.7150/thno.47485. eCollection 2020.
Ref 5 Taiwan cobra chymotrypsin inhibitor: cloning, functional expression and gene organization. Biochim Biophys Acta. 2005 Mar 14;1747(2):213-20. doi: 10.1016/j.bbapap.2004.11.006. Epub 2004 Dec 15.
Ref 6 Purification, characterization and primary structure of a chymotrypsin inhibitor from Naja atra venom. Comp Biochem Physiol B Biochem Mol Biol. 2004 Feb;137(2):219-24. doi: 10.1016/j.cbpc.2003.11.007.
Ref 7 NMR solution structure of a Chymotrypsin inhibitor from the Taiwan cobra Naja naja atra. Molecules. 2013 Jul 26;18(8):8906-18. doi: 10.3390/molecules18088906.
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