Peptide Information

General Information of This Peptide
Peptide ID
BTDP008390
Peptide Name
Kappa-stichotoxin-Hmg1a
Symonym
Potassium channel toxin HmK
Species
Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
Uniprot Name
1AK_HETMG
Alphafold ID
O16846
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: O16846
Sequence
MKSQMIAAVLLIAFCLCVVVTARMELQDVEDMENGFQKRRTCKDLIPVSECTDIRCRTSM
KYRLNLCRKTCGSC
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Sequence Length
74
Mass (Da)
8469
Signal Sequence
MKSQMIAAVLLIAFCLCVVVTA
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Sequence Removed Signal Peptide
RMELQDVEDMENGFQKRRTCKDLIPVSECTDIRCRTSMKYRLNLCRKTCGSC
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Disulfide Bond
42-74;51-67;56-71
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Heteractis
Species: Heteractis magnifica
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker-KcsA Inhibition constant
0.94 nM
 .
Blocker
 [4]
 Target Info    Shaker-KcsA Inhibition constant
1 nM
 .
Blocker
 [5]
 Target Info    Shaker Inhibition constant
1 nM
 .
Blocker
 [5]
 Target Info    Kv1.2 Inhibition constant
2.5 nM
 .
Blocker
 [5]
 Target Info    Kv1.3 Inhibition constant
3.1 nM
 .
Blocker
 [5]
 Target Info    Kv1 IC50
3.2 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.2 IC50
10 nM
 .
Blocker
 [1], [2], [3]
References
Ref 1 A new potassium channel toxin from the sea anemone Heteractis magnifica: isolation, cDNA cloning, and functional expression. Biochemistry. 1997 Sep 23;36(38):11461-71. doi: 10.1021/bi970253d.
Ref 2 Genomic structure of a potassium channel toxin from Heteractis magnifica. FEBS Lett. 1997 Nov 24;418(1-2):183-8. doi: 10.1016/s0014-5793(97)01365-3.
Ref 3 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 4 Tethered peptide neurotoxins display two blocking mechanisms in the K(+) channel pore as do their untethered analogs. Sci Adv. 2020 Mar 4;6(10):eaaz3439. doi: 10.1126/sciadv.aaz3439. eCollection 2020 Mar.
Ref 5 Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E7013-21. doi: 10.1073/pnas.1514728112. Epub 2015 Dec 1.
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