Target Information

General Information of This Target
Target ID
BTDT10073
Target Name
KcsA-Shaker
Target Bioclass
Transporter and channel
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N.A.
Species: Chimera
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Kappa-actitoxin-Aer3a Inhibition constant
0.3 nM
 [1]
 Toxin Info    Kappa-stichotoxin-Hmg1a Inhibition constant
0.94 nM
 [2]
 Toxin Info    Kappa-stichotoxin-Hmg1a Inhibition constant
1 nM
 [1]
 Toxin Info    Kappa-stichotoxin-She3a Inhibition constant
50 nM
 [1]
 Toxin Info    Potassium channel toxin HmK (Y23A) Inhibition constant
162 nM
 [2]
 Toxin Info    Potassium channel toxin HmK (K22N) Inhibition constant
225 nM
 [2]
References
Ref 1 Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E7013-21. doi: 10.1073/pnas.1514728112. Epub 2015 Dec 1.
Ref 2 Tethered peptide neurotoxins display two blocking mechanisms in the K(+) channel pore as do their untethered analogs. Sci Adv. 2020 Mar 4;6(10):eaaz3439. doi: 10.1126/sciadv.aaz3439. eCollection 2020 Mar.
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