Peptide Information

General Information of This Peptide
Peptide ID
BTDP000577
Peptide Name
Potassium channel toxin ShK (K22[Dap])
Symonym
Potassium channel toxin ShK (K22[Dap])
3D Structure
Original Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Mutant Sequence
RSCIDTIPKSRCTAFQCKHSM[Dap]YRLSFCRKTCGTC
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Sequence Length
35
Mass(Da)
4013
Sequence Removed Signal Peptide
RSCIDTIPKSRCTAFQCKHSM[Dap]YRLSFCRKTCGTC
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PDB ID
1BEI
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.024 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
0.052 nM
 .
Blocker
 [2]
 Target Info    Kv1.1 Dissociation constant
1.8 nM
 .
Blocker
 [2]
 Target Info    KCa3.1 Dissociation constant
2.6 μM
 .
Blocker
 [1]
 Target Info    Kv1.1 Inhibition constant
0.059 nM
 .
Blocker
 [3]
 Target Info    Kv1.3 Inhibition constant
0.198 nM
 .
Blocker
 [3]
 Target Info    Kv1.2-1.1 Inhibition constant
0.35 nM
 .
Blocker
 [3]
 Target Info    Kv1.2-1.1 Inhibition constant
0.35 nM
 .
Blocker
 [3]
 Target Info    Kv1.2 Inhibition constant
20.75 nM
 .
Blocker
 [3]
 Target Info    Kv3.1 Inhibition rate .
100 nM
Blocker
 [4]
 Target Info    Kv1.7 Inhibition rate .
100 nM
Blocker
 [4]
 Target Info    Kv3.4 Inhibition rate .
100 nM
Blocker
 [4]
 Target Info    Kv1.3 IC50
0.11 nM
 .
Blocker
 [3]
 Target Info    Kv1.1 IC50
0.847 nM
 .
Blocker
 [5]
 Target Info    Kv1.3 IC50
4.5 nM
 .
Blocker
 [3]
References
Ref 1 Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J Biol Chem. 1999 Jul 30;274(31):21885-92. doi: 10.1074/jbc.274.31.21885.
Ref 2 Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr;67(4):1369-81. doi: 10.1124/mol.104.008193. Epub 2005 Jan 21.
Ref 3 Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile. Biochemistry. 2003 Nov 25;42(46):13698-707. doi: 10.1021/bi035209e.
Ref 4 ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem. 1998 Dec 4;273(49):32697-707. doi: 10.1074/jbc.273.49.32697.
Ref 5 Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J Med Chem. 2015 Sep 10;58(17):6784-802. doi: 10.1021/acs.jmedchem.5b00495. Epub 2015 Aug 31.
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