Target Information

Target Name

Sodium channel protein type 8 subunit alpha

Target Bioclass

Transporter and channel

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N.A.
Species: Mammalian

General Information of This Target

Toxin Information Related to This Target

Toxin Name	Activity Data Type	Activity Data	Reference
Toxin Info NU-buthitoxin-Ptr1a	Effect	.	[1]
Toxin Info NU-theraphotoxin-Preg1a	Effect	.	[1]
Toxin Info Alpha-toxin OD1	Effective concentration 50	30 nM	[2], [3], [4], [5]
Toxin Info GAMMA-ctenitoxin-Pb1a	IC50	<1.5 μM	[6]

References

Ref 1	A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16.
Ref 2	OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS Lett. 2005 Aug 1;579(19):4181-6. doi: 10.1016/j.febslet.2005.06.052.
Ref 3	Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae. Mol Pharmacol. 2006 Jul;70(1):405-14. doi: 10.1124/mol.106.022970. Epub 2006 Apr 26.
Ref 4	Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016 Mar 17;8(3):78. doi: 10.3390/toxins8030078.
Ref 5	Chemical engineering and structural and pharmacological characterization of the -scorpion toxin OD1. ACS Chem Biol. 2013;8(6):1215-22. doi: 10.1021/cb400012k. Epub 2013 Apr 3.
Ref 6	Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae). Toxins (Basel). 2015 Jul 31;7(8):2872-87. doi: 10.3390/toxins7082872.

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