Peptide Information

General Information of This Peptide
Peptide ID
BTDP005589
Peptide Name
NU-buthitoxin-Ptr1a
Symonym
N-BUTX-Ptr1a; NU-BUTX-Ptr1a
Species
Parabuthus transvaalicus (South African fattail scorpion)
Uniprot Name
TXN1A_PARTR
Alphafold ID
P0DUJ3
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6SAB
Sequence
QMDMRCSASVECKQKCLKAIGSIFGKCMNKKCKC
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Sequence Length
34
Mass (Da)
3802
Sequence Removed Signal Peptide
QMDMRCSASVECKQKCLKAIGSIFGKCMNKKCKC
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Disulfide Bond
6-27;12-32;16-34
PDB ID
6SAB
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Parabuthus
Species: Parabuthus transvaalicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    melanocortin subtype MC5R Inhibition constant
2.2 μM
 . . [1]
 Target Info    melanocortin subtype MC4R Inhibition constant
2.6 μM
 . . [1]
 Target Info    melanocortin subtype MC1R Inhibition constant
2.9 μM
 . . [1]
 Target Info    melanocortin subtype MC3R Inhibition constant
3.9 μM
 . . [1]
 Target Info    GIRK1 Effect .
100 μM
 . [1]
 Target Info    nAChR alpha-7 Effect .
100 μM
 . [1]
 Target Info    nAChR alpha1-beta-1-gamma-delta Effect .
100 μM
 . [1]
 Target Info    Kv1.1 Effect .
100 μM
 . [1]
 Target Info    Kv1.2 Effect .
100 μM
 . [1]
 Target Info    Kv1.3 Effect .
100 μM
 . [1]
 Target Info    Kv1.4 Effect .
100 μM
 . [1]
 Target Info    Kv1.5 Effect .
100 μM
 . [1]
 Target Info    Kv1.6 Effect .
100 μM
 . [1]
 Target Info    Kv2.1 Effect .
100 μM
 . [1]
 Target Info    Kv3.1 Effect .
100 μM
 . [1]
 Target Info    Kv4.3 Effect .
100 μM
 . [1]
 Target Info    Kv10.1 Effect .
100 μM
 . [1]
 Target Info    Kv11.1 Effect .
100 μM
 . [1]
 Target Info    Kv7.1 Effect .
100 μM
 . [1]
 Target Info    Kv7.3 Effect .
100 μM
 . [1]
 Target Info    Nav1.8 Effect .
100 μM
 . [1]
 Target Info    Nav1.2 Effect .
100 μM
 . [1]
 Target Info    Nav1.3 Effect .
100 μM
 . [1]
 Target Info    Nav1.4 Effect .
100 μM
 . [1]
 Target Info    Nav1.5 Effect .
100 μM
 . [1]
 Target Info    Nav1.6 Effect .
100 μM
 . [1]
 Target Info    Nav1.7 Effect .
100 μM
 . [1]
References
Ref 1 A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16.
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