Peptide Information

General Information of This Peptide
Peptide ID
BTDP006622
Peptide Name
Alpha-toxin OD1
Species
Odontobuthus doriae (Yellow Iranian scorpion)
Uniprot Name
SCX1_ODODO
Alphafold ID
P84646
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 4HHF
Sequence
GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRI
PGKCR
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Sequence Length
65
Mass (Da)
7215
Sequence Removed Signal Peptide
GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRI
PGKCR
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Disulfide Bond
13-64;17-37;23-47;27-49
PDB ID
4HHF
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Odontobuthus
Species: Odontobuthus doriae
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 Effective concentration 50
4.5 nM
 . . [1], [2], [3], [4]
 Target Info    Nav1.4 Effective concentration 50
9.6 nM
 . . [1], [2], [3], [4]
 Target Info    Nav1.6 Effective concentration 50
30 nM
 . . [1], [2], [3], [4]
 Target Info    para/tipE Effective concentration 50
80 nM
 . . [1], [2], [3], [4]
References
Ref 1 OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS Lett. 2005 Aug 1;579(19):4181-6. doi: 10.1016/j.febslet.2005.06.052.
Ref 2 Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae. Mol Pharmacol. 2006 Jul;70(1):405-14. doi: 10.1124/mol.106.022970. Epub 2006 Apr 26.
Ref 3 Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016 Mar 17;8(3):78. doi: 10.3390/toxins8030078.
Ref 4 Chemical engineering and structural and pharmacological characterization of the -scorpion toxin OD1. ACS Chem Biol. 2013;8(6):1215-22. doi: 10.1021/cb400012k. Epub 2013 Apr 3.
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