Peptide Information

General Information of This Peptide
Peptide ID
BTDP005590
Peptide Name
NU-theraphotoxin-Preg1a
Symonym
N-TRTX-Preg1a; NU-TRTX-Preg1a
Species
Poecilotheria regalis (Indian ornamental tree spider)
Uniprot Name
TXN1A_POERG
Alphafold ID
P0DUJ4
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6SAA
Sequence
RCLHAGAACSGPIQKIPCCGTCSRRKCT
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Sequence Length
28
Mass (Da)
2922
Sequence Removed Signal Peptide
RCLHAGAACSGPIQKIPCCGTCSRRKCT
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Disulfide Bond
2-19;9-22;18-27
PDB ID
6SAA
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Poecilotheria
Species: Poecilotheria regalis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    melanocortin subtype MC1R Inhibition constant
1.8 μM
 . . [1]
 Target Info    melanocortin subtype MC4R Inhibition constant
7.1 μM
 . . [1]
 Target Info    melanocortin subtype MC5R Inhibition constant
10 μM
 . . [1]
 Target Info    melanocortin subtype MC3R Inhibition constant
19.8 μM
 . . [1]
 Target Info    GIRK1 Effect .
100 μM
 . [1]
 Target Info    nAChR alpha-7 Effect .
100 μM
 . [1]
 Target Info    nAChR alpha1-beta-1-gamma-delta Effect .
100 μM
 . [1]
 Target Info    Kv1.1 Effect .
100 μM
 . [1]
 Target Info    Kv1.2 Effect .
100 μM
 . [1]
 Target Info    Kv1.3 Effect .
100 μM
 . [1]
 Target Info    Kv1.4 Effect .
100 μM
 . [1]
 Target Info    Kv1.5 Effect .
100 μM
 . [1]
 Target Info    Kv1.6 Effect .
100 μM
 . [1]
 Target Info    Kv2.1 Effect .
100 μM
 . [1]
 Target Info    Kv3.1 Effect .
100 μM
 . [1]
 Target Info    Kv4.3 Effect .
100 μM
 . [1]
 Target Info    Kv10.1 Effect .
100 μM
 . [1]
 Target Info    Kv11.1 Effect .
100 μM
 . [1]
 Target Info    Kv7.1 Effect .
100 μM
 . [1]
 Target Info    Kv7.3 Effect .
100 μM
 . [1]
 Target Info    Nav1.8 Effect .
100 μM
 . [1]
 Target Info    Nav1.2 Effect .
100 μM
 . [1]
 Target Info    Nav1.3 Effect .
100 μM
 . [1]
 Target Info    Nav1.4 Effect .
100 μM
 . [1]
 Target Info    Nav1.5 Effect .
100 μM
 . [1]
 Target Info    Nav1.6 Effect .
100 μM
 . [1]
 Target Info    Nav1.7 Effect .
100 μM
 . [1]
 Target Info    Cav3.3 Effect .
100 μM
 . [1]
References
Ref 1 A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16.
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