Target Information

General Information of This Target
Target ID
BTDT10261
Target Name
Sodium channel protein type 3 subunit alpha
Target Bioclass
Transporter and channel
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N.A.
Species: Mammalian
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    NU-buthitoxin-Ptr1a Effect . [1]
 Toxin Info    NU-theraphotoxin-Preg1a Effect . [1]
 Toxin Info    GAMMA-ctenitoxin-Pn1a IC50
1.5 μM
 [2- 7]
 Toxin Info    GAMMA-ctenitoxin-Pb1a IC50
1.5 μM
 [8]
References
Ref 1 A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16.
Ref 2 Molecular cloning of cDNAs encoding insecticidal neurotoxic peptides from the spider Phoneutria nigriventer. Toxicon. 2000 Oct;38(10):1443-9. doi: 10.1016/s0041-0101(99)00237-8.
Ref 3 Purification and amino acid sequence of a highly insecticidal toxin from the venom of the brazilian spider Phoneutria nigriventer which inhibits NMDA-evoked currents in rat hippocampal neurones. Toxicon. 2001 Feb-Mar;39(2-3):309-17. doi: 10.1016/s0041-0101(00)00129-x.
Ref 4 Comparison of the partial proteomes of the venoms of Brazilian spiders of the genus Phoneutria. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Mar-Apr;142(3-4):173-187. doi: 10.1016/j.cbpc.2005.09.010. Epub 2005 Nov 8.
Ref 5 Differential effects of the recombinant toxin PnTx4(5-5) from the spider Phoneutria nigriventer on mammalian and insect sodium channels. Biochimie. 2016 Feb;121:326-35. doi: 10.1016/j.biochi.2015.12.019. Epub 2015 Dec 30.
Ref 6 The Phoneutria nigriventer spider toxin, PnTx4-5-5, promotes neuronal survival by blocking NMDA receptors. Toxicon. 2016 Mar 15;112:16-21. doi: 10.1016/j.toxicon.2016.01.056. Epub 2016 Jan 21.
Ref 7 Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system. J Venom Anim Toxins Incl Trop Dis. 2019 Aug 12;25:e20190022. doi: 10.1590/1678-9199-JVATITD-2019-0022. eCollection 2019.
Ref 8 Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae). Toxins (Basel). 2015 Jul 31;7(8):2872-87. doi: 10.3390/toxins7082872.
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