Peptide Information

General Information of This Peptide
Peptide ID
BTDP006147
Peptide Name
GAMMA-ctenitoxin-Pn1a
Symonym
Insecticidal neurotoxin Tx4(5-5); Toxin Pn4A
Species
Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Uniprot Name
TX35C_PHONI
Alphafold ID
P59367
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P59367
Sequence
MKVAIVFLSLLVLAFASESIEENREEFPVEESARCADINGACKSDCDCCGDSVTCDCYWS
DSCKCRESNFKIGMAIRKKFC
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Sequence Length
81
Mass (Da)
9021
Signal Sequence
MKVAIVFLSLLVLAFA
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Sequence Removed Signal Peptide
SESIEENREEFPVEESARCADINGACKSDCDCCGDSVTCDCYWSDSCKCRESNFKIGMAI
RKKFC
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Disulfide Bond
35-49;42-55;46-81;48-65;57-63
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Ctenidae
Genus: Phoneutria
Species: Phoneutria nigriventer
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    sodium channel Effective concentration 50
212.5 nM
 . . [1- 6]
 Target Info    Nav1.3 IC50
1.5 μM
 . . [1- 6]
References
Ref 1 Molecular cloning of cDNAs encoding insecticidal neurotoxic peptides from the spider Phoneutria nigriventer. Toxicon. 2000 Oct;38(10):1443-9. doi: 10.1016/s0041-0101(99)00237-8.
Ref 2 Purification and amino acid sequence of a highly insecticidal toxin from the venom of the brazilian spider Phoneutria nigriventer which inhibits NMDA-evoked currents in rat hippocampal neurones. Toxicon. 2001 Feb-Mar;39(2-3):309-17. doi: 10.1016/s0041-0101(00)00129-x.
Ref 3 Comparison of the partial proteomes of the venoms of Brazilian spiders of the genus Phoneutria. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Mar-Apr;142(3-4):173-187. doi: 10.1016/j.cbpc.2005.09.010. Epub 2005 Nov 8.
Ref 4 Differential effects of the recombinant toxin PnTx4(5-5) from the spider Phoneutria nigriventer on mammalian and insect sodium channels. Biochimie. 2016 Feb;121:326-35. doi: 10.1016/j.biochi.2015.12.019. Epub 2015 Dec 30.
Ref 5 The Phoneutria nigriventer spider toxin, PnTx4-5-5, promotes neuronal survival by blocking NMDA receptors. Toxicon. 2016 Mar 15;112:16-21. doi: 10.1016/j.toxicon.2016.01.056. Epub 2016 Jan 21.
Ref 6 Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system. J Venom Anim Toxins Incl Trop Dis. 2019 Aug 12;25:e20190022. doi: 10.1590/1678-9199-JVATITD-2019-0022. eCollection 2019.
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