Target Information

General Information of This Target
Target ID
BTDT10259
Target Name
Sodium channel protein type 2 subunit alpha
Target Bioclass
Transporter and channel
        Click to Show/Hide the Complete Species Lineage
N.A.
Species: Mammalian
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    NU-buthitoxin-Ptr1a Effect . [1]
 Toxin Info    NU-theraphotoxin-Preg1a Effect . [1]
 Toxin Info    Delta-actitoxin-Avd1c Effective concentration 50
7.88 nM
 [2- 8]
 Toxin Info    GAMMA-ctenitoxin-Pb1a IC50
<1.5 μM
 [9]
References
Ref 1 A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16.
Ref 2 Amino-acid sequence of a coelenterate toxin: toxin II from Anemonia sulcata. Eur J Biochem. 1976 Sep;68(1):193-8. doi: 10.1111/j.1432-1033.1976.tb10778.x.
Ref 3 [The disulfide bridges of toxin II from Anemonia sulcata (author's transl)]. Hoppe Seylers Z Physiol Chem. 1978 Sep;359(9):1193-201.
Ref 4 Anemonia sulcata toxins modify activation and inactivation of Na+ currents in a crayfish neurone. Pflugers Arch. 1985 May;404(2):119-25. doi: 10.1007/BF00585406.
Ref 5 Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel alpha-subunits expressed in tsA201 cells. J Membr Biol. 1996 Jul;152(1):39-48. doi: 10.1007/s002329900083.
Ref 6 Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. J Gen Physiol. 1997 Aug;110(2):119-33. doi: 10.1085/jgp.110.2.119.
Ref 7 Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop. J Biol Chem. 2004 Aug 6;279(32):33323-35. doi: 10.1074/jbc.M404344200. Epub 2004 May 28.
Ref 8 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 9 Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae). Toxins (Basel). 2015 Jul 31;7(8):2872-87. doi: 10.3390/toxins7082872.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.