Target Information

General Information of This Target
Target ID
BTDT10130
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-4-beta-2
Target Bioclass
Receptor
Taxonomy ID
9606
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Elevenin Effect . [1]
 Toxin Info    Elevenin Effect . [2]
 Toxin Info    Alpha-conotoxin FrXXA IC50
697 nM
 [3]
 Toxin Info    Alpha-conotoxin FrXXA 2 IC50
697 nM
 [3]
 Toxin Info    Haditoxin IC50
2.6 μM
 [4], [5], [6]
References
Ref 1 A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae). Toxins (Basel). 2021 Sep 10;13(9):642. doi: 10.3390/toxins13090642.
Ref 2 Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus. Mar Drugs. 2022 Feb 17;20(2):149. doi: 10.3390/md20020149.
Ref 3 A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors. Toxins (Basel). 2022 Jul 26;14(8):510. doi: 10.3390/toxins14080510.
Ref 4 Beta-cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity. FASEB J. 2007 Nov;21(13):3685-95. doi: 10.1096/fj.07-8658com. Epub 2007 Jul 6.
Ref 5 The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20651-6. doi: 10.1073/pnas.1314702110. Epub 2013 Dec 2.
Ref 6 Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra). J Biol Chem. 2010 Mar 12;285(11):8302-15. doi: 10.1074/jbc.M109.074161. Epub 2010 Jan 13.
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