Peptide Information

General Information of This Peptide
Peptide ID
BTDP001989
Peptide Name
Haditoxin
Symonym
Muscarinic toxin-like protein 3 homolog
Species
Ophiophagus hannah (King cobra) (Naja hannah)
Uniprot Name
3SO8_OPHHA
Alphafold ID
A8N286
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 3HH7
Sequence
MKTLLLTLVVVTIVYLDLGYTTKCYNHQSTTPETTEICPDSGYFCYKSSWIDGREGRIER
GCTFTCPELTPNGKYVYCCRRDKCNQ
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Sequence Length
86
Mass (Da)
9893
Signal Sequence
MKTLLLTLVVVTIVYLDLGYT
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Sequence Removed Signal Peptide
TKCYNHQSTTPETTEICPDSGYFCYKSSWIDGREGRIERGCTFTCPELTPNGKYVYCCRR
DKCNQ
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Disulfide Bond
24-45;38-62;66-78;79-84
PDB ID
3HH7
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Ophiophagus
Species: Ophiophagus hannah
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7 IC50
180 nM
 .
Antagonist
[1], [2], [3]
 Target Info    nAChR alpha-3-beta-2 IC50
500 nM
 .
Antagonist
[1], [2], [3]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
550 nM
 .
Antagonist
[1], [2], [3]
 Target Info    nAChR alpha-4-beta-2 IC50
2.6 μM
 .
Antagonist
[1], [2], [3]
References
Ref 1 Beta-cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity. FASEB J. 2007 Nov;21(13):3685-95. doi: 10.1096/fj.07-8658com. Epub 2007 Jul 6.
Ref 2 The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20651-6. doi: 10.1073/pnas.1314702110. Epub 2013 Dec 2.
Ref 3 Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra). J Biol Chem. 2010 Mar 12;285(11):8302-15. doi: 10.1074/jbc.M109.074161. Epub 2010 Jan 13.
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