Peptide Information

General Information of This Peptide
Peptide ID
BTDP005431
Peptide Name
Alpha-conotoxin FrXXA
Symonym
Toxin 1
Species
Conus fergusoni (Ferguson's cone)
Uniprot Name
CDKA1_CONFE
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
MPKLEMMLLVLLILPLSYFDSAGGQAVKVDGHGDGMDRYLQRDDREARITCQPRGRSKWG
RCCLTQMCGNFCCPRYGCRCVYRSGRGHGCSC
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Sequence Length
92
Mass (Da)
10356
Signal Sequence
MPKLEMMLLVLLILPLSYFDSAGG
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Sequence Removed Signal Peptide
QAVKVDGHGDGMDRYLQRDDREARITCQPRGRSKWGRCCLTQMCGNFCCPRYGCRCVYRS
GRGHGCSC
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus fergusoni
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7 IC50
125 nM
 . . [1]
 Target Info    nAChR alpha-3-beta-2 IC50
282 nM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
351 nM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
447 nM
 . . [1]
 Target Info    nAChR alpha-4-beta-2 IC50
697 nM
 . . [1]
References
Ref 1 A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors. Toxins (Basel). 2022 Jul 26;14(8):510. doi: 10.3390/toxins14080510.
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