Target Information

General Information of This Target
Target ID
BTDT10098
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-1-beta-1-epsilon-delta
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Alpha-conotoxin PIVA IC50
22 nM
 [1], [2], [3]
 Toxin Info    Alpha/kappa-conotoxin pl14a IC50
0.54 μM
 [4]
 Toxin Info    Alpha-conotoxin PeIVA IC50
4 μM
 [2]
 Toxin Info    Alpha-conotoxin OIVB IC50
96 μM
 [5], [2]
References
Ref 1 A new family of Conus peptides targeted to the nicotinic acetylcholine receptor. J Biol Chem. 1995 Sep 22;270(38):22361-7. doi: 10.1074/jbc.270.38.22361.
Ref 2 Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor. Biochemistry. 2006 Jan 31;45(4):1304-12. doi: 10.1021/bi052016d.
Ref 3 NMR structure determination of a novel conotoxin, [Pro 7,13] alpha A-conotoxin PIVA. Biochemistry. 1997 Feb 18;36(7):1669-77. doi: 10.1021/bi962301k.
Ref 4 A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry. 2006 Jul 11;45(27):8331-40. doi: 10.1021/bi060263r.
Ref 5 A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor. J Neurosci. 2005 Jan 19;25(3):732-6. doi: 10.1523/JNEUROSCI.4065-04.2005.
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