Peptide Information

General Information of This Peptide
Peptide ID
BTDP004088
Peptide Name
Alpha-conotoxin OIVB
Symonym
Alpha-A-O4b; Alpha-A-OIVB
Species
Conus obscurus (Obscure cone) (Conus halitropus)
Uniprot Name
CA4B_CONOB
Alphafold ID
P0C1W8
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C1W8
Sequence
CCGVPNAACPPCVCNKTCG
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Sequence Length
19
Mass (Da)
1840
Sequence Removed Signal Peptide
CCGVPNAACPPCVCNKTCG
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Disulfide Bond
1-9;2-14;12-18
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
66 nM
 . . [1], [2]
 Target Info    nAChR alpha-1-beta-1-epsilon-delta IC50
96 μM
 . . [1], [2]
References
Ref 1 A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor. J Neurosci. 2005 Jan 19;25(3):732-6. doi: 10.1523/JNEUROSCI.4065-04.2005.
Ref 2 Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor. Biochemistry. 2006 Jan 31;45(4):1304-12. doi: 10.1021/bi052016d.
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