Peptide Information

General Information of This Peptide
Peptide ID
BTDP006029
Peptide Name
Alpha-conotoxin PIVA
Symonym
Alpha-A-conotoxin PIVA
Species
Conus purpurascens (Purple cone)
Uniprot Name
CA4A_CONPU
Alphafold ID
P55963
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1P1P
Sequence
MFTVFLLVVLATTVVSFTSDRASDDRNTNDKASRLLSHVVRGCCGSYPNAACHPCSCKDR
PSYCGQGR
   Click to Show/Hide
Sequence Length
68
Mass (Da)
7386
Signal Sequence
MFTVFLLVVLATTVVS
   Click to Show/Hide
Sequence Removed Signal Peptide
FTSDRASDDRNTNDKASRLLSHVVRGCCGSYPNAACHPCSCKDRPSYCGQGR
   Click to Show/Hide
Disulfide Bond
43-57;44-52;55-64
PDB ID
1P1P
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus purpurascens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
2.3 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-1-beta-1-epsilon-delta IC50
22 nM
 . . [1], [2], [3]
References
Ref 1 A new family of Conus peptides targeted to the nicotinic acetylcholine receptor. J Biol Chem. 1995 Sep 22;270(38):22361-7. doi: 10.1074/jbc.270.38.22361.
Ref 2 Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor. Biochemistry. 2006 Jan 31;45(4):1304-12. doi: 10.1021/bi052016d.
Ref 3 NMR structure determination of a novel conotoxin, [Pro 7,13] alpha A-conotoxin PIVA. Biochemistry. 1997 Feb 18;36(7):1669-77. doi: 10.1021/bi962301k.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.