Target Information

General Information of This Target
Target ID
BTDT10041
Target Name
DRG neuron
Target Bioclass
Cells
Taxonomy ID
10116
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mu-theraphotoxin-Pn3a Inhibition rate
55 %
 [1- 6]
 Toxin Info    FMRFamide-like peptide Sa12b IC50
81 nM
 [7], [8], [9]
 Toxin Info    U18-theraphotoxin-Cg1a IC50
0.6 μM
 [10], [11], [12]
 Toxin Info    U18-theraphotoxin-Cg1a IC50
0.95 μM
 [10], [11], [12]
 Toxin Info    Conotoxin Vr3a IC50
19.28 μM
 [13], [14]
References
Ref 1 Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883.
Ref 2 Corrigendum: Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816.
Ref 3 Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain. 2019 Aug;160(8):1766-1780. doi: 10.1097/j.pain.0000000000001567.
Ref 4 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
Ref 5 Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels. Front Pharmacol. 2021 Jan 28;11:633679. doi: 10.3389/fphar.2020.633679. eCollection 2020.
Ref 6 -Theraphotoxin Pn3a inhibition of Ca(V)3.3 channels reveals a novel isoform-selective drug binding site. Elife. 2022 Jul 20;11:e74040. doi: 10.7554/eLife.74040.
Ref 7 Sa12b Peptide from Solitary Wasp Inhibits ASIC Currents in Rat Dorsal Root Ganglion Neurons. Toxins (Basel). 2019 Oct 10;11(10):585. doi: 10.3390/toxins11100585.
Ref 8 Isolation and characterization of FMRFamide-like peptides in the venoms of solitary sphecid wasps. Peptides. 2021 Aug;142:170575. doi: 10.1016/j.peptides.2021.170575. Epub 2021 May 20.
Ref 9 Peptide Toxins in Solitary Wasp Venoms. Toxins (Basel). 2016 Apr 18;8(4):114. doi: 10.3390/toxins8040114.
Ref 10 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 11 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 12 Jingzhaotoxin-IX, a novel gating modifier of both sodium and potassium channels from Chinese tarantula Chilobrachys jingzhao. Neuropharmacology. 2009 Aug;57(2):77-87. doi: 10.1016/j.neuropharm.2009.04.009. Epub 2009 May 4.
Ref 13 Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon. 2013 Dec 15;76:150-9. doi: 10.1016/j.toxicon.2013.09.020. Epub 2013 Sep 27.
Ref 14 A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents. J Venom Anim Toxins Incl Trop Dis. 2021 Jun 11;27:e20200164. doi: 10.1590/1678-9199-JVATITD-2020-0164. eCollection 2021.
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