Peptide Information

General Information of This Peptide
Peptide ID
BTDP008361
Peptide Name
Conotoxin Vr3a
Symonym
Vr3-NPPP01
Species
Conus varius (Varius cone)
Uniprot Name
CM3A_CONVA
Alphafold ID
H2BK78
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: H2BK78
Sequence
MLKMGVVLFTVLVLFPLATLHLDAEQPVERYAENKQDINPDQRSGFLTFALRQGCCPPGV
CQMAACNPPPCCP
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Sequence Length
73
Mass (Da)
8005
Signal Sequence
MLKMGVVLFTVLVLFPLATLHL
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Sequence Removed Signal Peptide
DAEQPVERYAENKQDINPDQRSGFLTFALRQGCCPPGVCQMAACNPPPCCP
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Disulfide Bond
55-66;56-71;61-72
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus varius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv Inhibition rate
10 %
100 μM
Blocker
 [1]
 Target Info    Cav2.2 Inhibition rate
12.86 %
10 μM
Blocker
 [1], [2]
 Target Info    Cav1.2 Inhibition rate
15.32 %
10 μM
Blocker
 [1], [2]
 Target Info    DRG neuron IC50
19.28 μM
 .
Blocker
 [1], [2]
References
Ref 1 A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents. J Venom Anim Toxins Incl Trop Dis. 2021 Jun 11;27:e20200164. doi: 10.1590/1678-9199-JVATITD-2020-0164. eCollection 2021.
Ref 2 Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon. 2013 Dec 15;76:150-9. doi: 10.1016/j.toxicon.2013.09.020. Epub 2013 Sep 27.
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