Peptide Information

General Information of This Peptide
Peptide ID
BTDP008426
Peptide Name
Mambaquaretin-7
Symonym
Kunitz-type serine protease inhibitor homolog dendrotoxin B; Mambaquaretin-8; Protein B; Upsilon-Dp2b; Upsilon-Dp2c; Venom basic protease inhibitor B
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
MAMB7_DENPO
Alphafold ID
P00983
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P00983
Sequence
RPYACELIVAAGPCMFFISAFYYSKGANKCYPFTYSGCRGNANRFKTIEECRRTCVV
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Sequence Length
57
Mass (Da)
6476
Sequence Removed Signal Peptide
RPYACELIVAAGPCMFFISAFYYSKGANKCYPFTYSGCRGNANRFKTIEECRRTCVV
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Disulfide Bond
5-55;14-38;30-51
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    V2R Inhibition constant
3.14 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1 Inhibition rate
80 %
3 nM
Blocker
 [3]
 Target Info    V1a2R IC50
58 nM
 .
Blocker
 [1], [2]
References
Ref 1 The amino acid sequence of a weak trypsin inhibitor B from Dendroaspis Polylepis polylepis (black mamba) venom. Hoppe Seylers Z Physiol Chem. 1981 Oct;362(10):1377-84. doi: 10.1515/bchm2.1981.362.2.1377.
Ref 2 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28.
Ref 3 Purification and partial characterization of K+ channel blockers from the venom of Dendroaspis angusticeps. Neurochem Int. 1992 Jun;20(4):553-8. doi: 10.1016/0197-0186(92)90034-o.
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