Peptide Information

General Information of This Peptide
Peptide ID
BTDP007359
Peptide Name
Kunitz-type serine protease inhibitor NACI
Symonym
Naja atra chymotrypsin inhibitor
Species
Naja atra (Chinese cobra)
Uniprot Name
VKT_NAJAT
Alphafold ID
Q5ZPJ7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2M99
Sequence
MSSGGLLLLLGLLTLWAELTPVSGRPRFCELAPSAGSCFAFVPSYYYNQYSNTCHSFTYS
GCGGNANRFRTIDECNRTCVG
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Sequence Length
81
Mass (Da)
8815
Signal Sequence
MSSGGLLLLLGLLTLWAELTPVSG
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Sequence Removed Signal Peptide
RPRFCELAPSAGSCFAFVPSYYYNQYSNTCHSFTYSGCGGNANRFRTIDECNRTCVG
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Disulfide Bond
29-79;38-62;54-75
PDB ID
2M99
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja atra
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    chymotrypsin Inhibition constant
25 nM
 . . [1], [2], [3], [4]
 Target Info    V2R Inhibition constant
112 nM
 . . [1], [2], [3], [4]
References
Ref 1 Taiwan cobra chymotrypsin inhibitor: cloning, functional expression and gene organization. Biochim Biophys Acta. 2005 Mar 14;1747(2):213-20. doi: 10.1016/j.bbapap.2004.11.006. Epub 2004 Dec 15.
Ref 2 Purification, characterization and primary structure of a chymotrypsin inhibitor from Naja atra venom. Comp Biochem Physiol B Biochem Mol Biol. 2004 Feb;137(2):219-24. doi: 10.1016/j.cbpc.2003.11.007.
Ref 3 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28.
Ref 4 NMR solution structure of a Chymotrypsin inhibitor from the Taiwan cobra Naja naja atra. Molecules. 2013 Jul 26;18(8):8906-18. doi: 10.3390/molecules18088906.
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