Peptide Information

General Information of This Peptide
Peptide ID
BTDP008705
Peptide Name
Potassium channel toxin alpha-KTx 2.13
Symonym
Toxin Css20
Species
Centruroides suffusus (Durango bark scorpion)
Uniprot Name
KAX2D_CENSU
Alphafold ID
P85529
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P85529
Sequence
IFINVKCSSPQQCLKPCKAAFGISAGGKCINGKCKCYP
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Sequence Length
38
Mass (Da)
4007
Sequence Removed Signal Peptide
IFINVKCSSPQQCLKPCKAAFGISAGGKCINGKCKCYP
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Disulfide Bond
7-29;13-34;17-36
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides suffusus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Dissociation constant
1.3 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
7.2 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.2 IC50
1.3 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
7.2 nM
 .
Blocker
 [1]
References
Ref 1 A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus. Biochem Pharmacol. 2008 Oct 30;76(9):1142-54. doi: 10.1016/j.bcp.2008.08.018. Epub 2008 Aug 22.
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