Peptide Information

General Information of This Peptide
Peptide ID
BTDP008694
Peptide Name
Potassium channel toxin kappa-KTx 1.3
Symonym
Kappa-hefutoxin 3
Species
Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
Uniprot Name
KKX13_HETSP
Alphafold ID
P83655
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P83655
Sequence
GFGCYRSCWKAGHDEETCKKECS
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Sequence Length
23
Mass (Da)
2625
Sequence Removed Signal Peptide
GFGCYRSCWKAGHDEETCKKECS
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Disulfide Bond
4-22;8-18
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Heterometrus
Species: Heterometrus spinifer
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 Inhibition rate .
1 mM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
1 mM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
1 mM
Blocker
 [1]
 Target Info    Kv10 Inhibition rate
6.2 %
40 μM
Blocker
 [2]
 Target Info    Kv11.1 Inhibition rate
6.2 %
40 μM
Blocker
 [1], [2]
References
Ref 1 Assignment of voltage-gated potassium channel blocking activity to kappa-KTx1.3, a non-toxic homologue of kappa-hefutoxin-1, from Heterometrus spinifer venom. Biochem Pharmacol. 2005 Feb 15;69(4):669-78. doi: 10.1016/j.bcp.2004.10.018. Epub 2004 Dec 29.
Ref 2 Expanding the pharmacological profile of -hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1. Peptides. 2017 Dec;98:43-50. doi: 10.1016/j.peptides.2016.08.008. Epub 2016 Aug 28.
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