Peptide Information

General Information of This Peptide
Peptide ID
BTDP008654
Peptide Name
Potassium channel toxin alpha-KTx 3.1
Symonym
Kaliotoxin; Kaliotoxin-1
Species
Androctonus mauritanicus mauritanicus (Scorpion)
Uniprot Name
KAX31_ANDMA
Alphafold ID
P24662
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1KTX
Sequence
GVEINVKCSGSPQCLKPCKDAGMRFGKCMNRKCHCTPK
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Sequence Length
38
Mass (Da)
4156
Sequence Removed Signal Peptide
GVEINVKCSGSPQCLKPCKDAGMRFGKCMNRKCHCTPK
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Disulfide Bond
8-28;14-33;18-35
PDB ID
1KTX , 1XSW , 2KTX , 2UVS , 3ODV
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus mauritanicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.1 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
0.65 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1 Dissociation constant
1.1 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 Dissociation constant
20 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.1 Dissociation constant
41 nM
 .
Blocker
 [1- 8]
 Target Info    KCa1.1 Dissociation constant
1.56 μM
 .
Blocker
 [1]
 Target Info    Kv1.2 Inhibition constant
2.3 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 Inhibition constant
6.3 nM
 .
Blocker
 [1- 8]
 Target Info    KCa1.1 Inhibition constant
1.56 μM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2-1.2-1.2-1.2 Inhibition rate .
100 nM
Blocker
 [9]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [1- 8]
 Target Info    Kv1.2 IC50
4.4 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 IC50
6 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 IC50
6.4 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 IC50
7 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 IC50
11 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1 IC50
36 nM
 .
Blocker
 [1- 8]
References
Ref 1 A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22211-6. doi: 10.1073/pnas.0910123106. Epub 2009 Dec 10.
Ref 2 Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom. J Biol Chem. 1992 Jan 25;267(3):1640-7.
Ref 3 Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34.
Ref 4 Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18.
Ref 5 Kaliotoxin (1-37) shows structural differences with related potassium channel blockers. Biochemistry. 1994 Nov 29;33(47):14256-63. doi: 10.1021/bi00251a038.
Ref 6 3D structure of kaliotoxin: is residue 34 a key for channel selectivity?. J Pept Sci. 1997 Jul-Aug;3(4):314-9. doi: 10.1002/(SICI)1099-1387(199707)3:4%3C314::AID-PSC117%3E3.0.CO;2-E.
Ref 7 A concept for rapid protein-structure determination by solid-state NMR spectroscopy. Angew Chem Int Ed Engl. 2005 Mar 29;44(14):2089-92. doi: 10.1002/anie.200462516.
Ref 8 Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR. Nature. 2006 Apr 13;440(7086):959-62. doi: 10.1038/nature04649.
Ref 9 Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol. 2010 Sep;136(3):273-82. doi: 10.1085/jgp.200910398.
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