Peptide Information

General Information of This Peptide
Peptide ID
BTDP008650
Peptide Name
Defensin BmKDfsin4
Symonym
4 kDa defensin
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
DEF4_MESMA
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
MKTIVLLFVLALVFCTLEMGIVEAGFGCPFNQGQCHKHCQSIRRRGGYCDGFLKQRCVCY
RK
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Sequence Length
62
Mass (Da)
7074
Sequence Removed Signal Peptide
GFGCPFNQGQCHKHCQSIRRRGGYCDGFLKQRCVCYRK
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Disulfide Bond
28-49;35-57;39-59
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate
3.9 %
1 μM
 . [1], [2], [3]
 Target Info    KCa3.1 Inhibition rate
4 %
1 μM
Blocker
 [2]
 Target Info    Kv7 Inhibition rate
5.9 %
1 μM
 . [1], [2], [3]
 Target Info    Kv7.1 Inhibition rate
6 %
1 μM
Blocker
 [2]
 Target Info    KCa2.3 Inhibition rate
7 %
1 μM
 . [1], [2], [3]
 Target Info    KCa2.3 Inhibition rate
7 %
1 μM
Blocker
 [2]
 Target Info    Kv11.1 Inhibition rate
11.6 %
1 μM
 . [1], [2], [3]
 Target Info    Kv11 Inhibition rate
12 %
1 μM
Blocker
 [2]
 Target Info    Kv1.1 Inhibition rate
25 %
1 μM
Blocker
 [2]
 Target Info    Kv1.1 Inhibition rate
25.2 %
1 μM
 . [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate
30.5 %
1 μM
 . [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate
31 %
1 μM
Blocker
 [2]
 Target Info    Kv1.3 Inhibition rate
61 %
1 μM
 . [1], [2], [3]
 Target Info    Kv1.3 IC50
510 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
510.2 nM
 . . [1], [2], [3]
References
Ref 1 The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun. 2013;4:2602. doi: 10.1038/ncomms3602.
Ref 2 Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin. J Biol Chem. 2016 Mar 25;291(13):7097-106. doi: 10.1074/jbc.M115.680611. Epub 2016 Jan 27.
Ref 3 A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro. Toxins (Basel). 2016 Apr 27;8(5):124. doi: 10.3390/toxins8050124.
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