Peptide Information

General Information of This Peptide
Peptide ID
BTDP008644
Peptide Name
U-actitoxin-Avd3n
Symonym
AsKC11
Species
Anemonia viridis (Snakelocks anemone)
Uniprot Name
VKTB_ANEVI
Alphafold ID
P0DN15
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DN15
Sequence
MVFLLCFFLVADVSYGINKDCLLPKVVGFCRARFPRYYYNSSSRRCEKFIYGGCGGNANN
FSSYYECHIKCFGPRAIIFPEDSPKEN
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Sequence Length
87
Mass (Da)
10006
Sequence Removed Signal Peptide
INKDCLLPKVVGFCRARFPRYYYNSSSRRCEKFIYGGCGGNANNFSSYYECHIKCFGPR
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Disulfide Bond
21-71;30-54;46-67
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anemonia
Species: Anemonia viridis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kir2.1 Inhibition rate .
48 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate
13.5 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.6 Inhibition rate
14 %
1 μM
Blocker
 [1]
 Target Info    Kir3.1/3.2 Effective concentration 50
80.9 μM
 .
Blocker
 [1]
 Target Info    GIRK1/2 Effective concentration 50
80.9 μM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 AsKC11, a Kunitz Peptide from Anemonia sulcata, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels. Mar Drugs. 2022 Feb 15;20(2):140. doi: 10.3390/md20020140.
Ref 2 Comprehensive EST analysis of the symbiotic sea anemone, Anemonia viridis. BMC Genomics. 2009 Jul 23;10:333. doi: 10.1186/1471-2164-10-333.
Ref 3 The mining of toxin-like polypeptides from EST database by single residue distribution analysis. BMC Genomics. 2011 Jan 31;12:88. doi: 10.1186/1471-2164-12-88.
Ref 4 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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