Peptide Information

General Information of This Peptide
Peptide ID
BTDP008637
Peptide Name
Potassium channel toxin alpha-KTx 6.21
Symonym
Urotoxin
Species
Urodacus yaschenkoi (Inland robust scorpion)
Uniprot Name
KAX6L_UROYA
Alphafold ID
P0DL37
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6MZT
Sequence
MNAKLIYLLLVVTTMMLTFDTTQAGDIKCSGTRQCWGPCKKQTTCTNSKCMNGKCKCYGC
VG
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Sequence Length
62
Mass (Da)
6793
Sequence Removed Signal Peptide
GDIKCSGTRQCWGPCKKQTTCTNSKCMNGKCKCYGCV
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Disulfide Bond
29-50;35-55;39-57;45-60
PDB ID
6MZT
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Urodacus
Species: Urodacus yaschenkoi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.5 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.2 IC50
0.11 - 0.16 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 IC50
0.16 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 IC50
70 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 IC50
70 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
91 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
91 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.1 IC50
253 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
253 nM
 .
Blocker
 [1], [2]
References
Ref 1 Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi. Mol Pharmacol. 2014 Jul;86(1):28-41. doi: 10.1124/mol.113.090183. Epub 2014 Apr 10.
Ref 2 Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochem Pharmacol. 2020 Apr;174:113782. doi: 10.1016/j.bcp.2019.113782. Epub 2019 Dec 25.
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