Peptide Information

General Information of This Peptide
Peptide ID
BTDP008588
Peptide Name
Potassium channel toxin alpha-KTx 2.15
Symonym
Toxin II.10.5
Species
Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Uniprot Name
KAX2F_CENTE
Alphafold ID
C0HJW1
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HJW1
Sequence
IFINVKCSSPQQCLKPCKKAFGQHAGGKCINGKCKCYP
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Sequence Length
38
Mass (Da)
4129
Sequence Removed Signal Peptide
IFINVKCSSPQQCLKPCKKAFGQHAGGKCINGKCKCYP
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Disulfide Bond
7-29;13-34;17-36
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides tecomanus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.2 IC50
0.3 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
0.3 nM
 .
With inactivation domain removed
 [1]
 Target Info    KCa3.1 IC50
6.4 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 IC50
6.4 nM
 .
With inactivation domain removed
 [1]
 Target Info    Kv1.3 IC50
8.3 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
8.3 nM
 .
With inactivation domain removed
 [1]
 Target Info    Shaker IR potassium channel IC50
12 nM
 .
With inactivation domain removed
 [1]
 Target Info    Shaker-IR IC50
22 nM
 .
Blocker
 [1]
References
Ref 1 Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus. Toxicon. 2016 Jun 1;115:1-12. doi: 10.1016/j.toxicon.2016.02.017. Epub 2016 Feb 26.
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