Target Information

General Information of This Target
Target ID
BTDT00170
Target Name
Potassium voltage-gated channel subfamily B member 1
Target Bioclass
Transporter and channel
Uniprot ID
Q91593
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene ID
378535
Synonym
Voltage-gated potassium channel subunit Kv2.1
Sequence
MPGWMNKHGSRSTTSLPPDPMDIIRSKACSRRVKVNVGGLAHEVLWRTLDRLPRTRLGKL
RDCNTNECLMEICDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFSQELD
YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREKEGDEFDNTCCADKRKKLWDLLE
KPNSSVAAKILAIISILFIVLSTIALSLNTLPDLQAIDEFGQTTDNAQLAHVEAVCIAWF
TMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR
IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK
FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY
KEQKRQEKAVKRREALERAKRNGSIVSMNMKDAFARSVELMDVVVEKTDETSGRKDKVQD
NHLSPSRWKWKKRTLSETSSNKSFDAKEQGSPEKTRSGSSPQNLNVQQLEDIYNKMAKTQ
SQPILNSKDLNQPSKPAEELEMGSIPGPTVPMLATHREGFIDMRSMSSIDSFISCTAEFP
ESGRFSHSPLAILPYRMNVNSGQNTSHGYKESRVRPLSSDVSRESFTEVHPKTDLSRHAT
YILESPKTLVKVKNPLMLRSLKVNFLEGETSSLLPAPNVLSPTSHRQEGPSNQDTSFIYE
HSVQSPETSLYTTASARTPSKSPEKHMAIDFTFHDANVHKYIDADTDDEGQLLDGLDSSP
SKELLGTMSPKYNITKSGHRTQRDNVHRGDKNHLEGAPFLSSSRYVGQNCIYATEGMTGR
RQGNLETVKMENHISPQVHVLPGGGGGHSNKHNPSI

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Family
the potassium channel family
Taxonomy ID
8355
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Kingdom: Metazoa
Phylum: Chordata
Class: Amphibia
Order: Anura
Family: Pipidae
Genus: Xenopus
Species: Xenopus laevis
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    U18-theraphotoxin-Cg1a IC50
604 nM
 [1], [2], [3]
References
Ref 1 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Jingzhaotoxin-IX, a novel gating modifier of both sodium and potassium channels from Chinese tarantula Chilobrachys jingzhao. Neuropharmacology. 2009 Aug;57(2):77-87. doi: 10.1016/j.neuropharm.2009.04.009. Epub 2009 May 4.
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