Target Information

General Information of This Target
Target ID
BTDT10230
Target Name
Potassium voltage-gated channel subfamily KQT member 5
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    U-scoloptoxin(15)-Sm2a Effect . [1], [2]
 Toxin Info    Mu-scoloptoxin(15)-Ssm1a IC50
2.7 μM
 [3]
References
Ref 1 Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (centipedes). Mol Biol Evol. 2014 Aug;31(8):2124-48. doi: 10.1093/molbev/msu162. Epub 2014 May 20.
Ref 2 A Centipede Toxin Family Defines an Ancient Class of CS Defensins. Structure. 2019 Feb 5;27(2):315-326.e7. doi: 10.1016/j.str.2018.10.022. Epub 2018 Dec 13.
Ref 3 Centipedes subdue giant prey by blocking KCNQ channels. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1646-1651. doi: 10.1073/pnas.1714760115. Epub 2018 Jan 22.
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