Peptide Information

General Information of This Peptide
Peptide ID
BTDP008512
Peptide Name
Potassium channel toxin alpha-KTx 6.12
Symonym
Anuroctoxin
Species
Anuroctonus phaiodactylus (Mafia scorpion)
Uniprot Name
KAX6C_ANUPH
Alphafold ID
P0C166
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C166
Sequence
QKECTGPQHCTNFCRKNKCTHGKCMNRKCKCFNCK
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Sequence Length
35
Mass (Da)
4109
Sequence Removed Signal Peptide
QKECTGPQHCTNFCRKNKCTHGKCMNRKCKCFNCK
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Disulfide Bond
4-24;10-29;14-31;19-34
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Chactidae
Genus: Anuroctonus
Species: Anuroctonus phaiodactylus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.73 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
6.14 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Shaker Inhibition rate
20 %
10 nM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate
20 %
10 nM
Blocker
 [1]
References
Ref 1 Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes. Mol Pharmacol. 2005 Apr;67(4):1034-44. doi: 10.1124/mol.104.007187. Epub 2004 Dec 22.
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