Peptide Information

General Information of This Peptide
Peptide ID
BTDP008466
Peptide Name
Potassium channel toxin alpha-KTx 15.2
Symonym
BmTX3; BmTX3A
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KA152_MESMA
Alphafold ID
Q8I0L5
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: Q8I0L5
Sequence
MKFSSIILLTLLICSMSKFGNCQVETNVKCQGGSCASVCRKAIGVAAGKCINGRCVCYP
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Sequence Length
59
Mass (Da)
6206
Signal Sequence
MKFSSIILLTLLICSMSKFGNC
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Sequence Removed Signal Peptide
QVETNVKCQGGSCASVCRKAIGVAAGKCINGRCVCYP
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Disulfide Bond
30-50;35-55;39-57
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv11 Dissociation constant
1.9 μM
 .
Blocker
 [1]
 Target Info    Kv4 Inhibition constant
54 nM
 .
Blocker
 [1- 6]
 Target Info    Kv1 Inhibition rate .
5 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
5 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
5 μM
Blocker
 [1]
 Target Info    Kv7.1 Inhibition rate .
5 μM
Blocker
 [1]
References
Ref 1 BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochem J. 2004 Mar 15;378(Pt 3):745-52. doi: 10.1042/BJ20031324.
Ref 2 A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and localization in rat brain. FEBS Lett. 2001 Jul 13;501(1):31-6. doi: 10.1016/s0014-5793(01)02620-5.
Ref 3 Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur J Biochem. 2002 Dec;269(24):6037-41. doi: 10.1046/j.1432-1033.2002.03294.x.
Ref 4 Kv4 channels sensitive to BmTX3 in rat nervous system: autoradiographic analysis of their distribution during brain ontogenesis. Eur J Neurosci. 2006 Sep;24(5):1325-40. doi: 10.1111/j.1460-9568.2006.05020.x.
Ref 5 Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. 2013 May 15;591(10):2419-27. doi: 10.1113/jphysiol.2012.248831. Epub 2013 Feb 25.
Ref 6 Functional consequences of deleting the two C-terminal residues of the scorpion toxin BmTX3. Biochim Biophys Acta. 2003 Mar 21;1646(1-2):152-6. doi: 10.1016/s1570-9639(02)00557-5.
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