Target Information

General Information of This Target
Target ID
BTDT10209
Target Name
Potassium voltage-gated channel subfamily D
Target Bioclass
Transporter and channel
Taxonomy ID
10116
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Neurotoxin AamTX Dissociation constant
0.066 nM
 [1]
 Toxin Info    Potassium channel toxin alpha-KTx 15.7 Inhibition constant
0.02 nM
 [2]
 Toxin Info    Potassium channel toxin alpha-KTx 15.1 Inhibition constant
0.044 nM
 [3], [4]
 Toxin Info    Potassium channel toxin alpha-KTx 15.2 Inhibition constant
54 nM
 [1- 9]
 Toxin Info    Potassium channel toxin alpha-KTx 15.7 Inhibition constant
131 nM
 [2]
 Toxin Info    Potassium channel toxin alpha-KTx 15.1 Inhibition constant
150 nM
 [3], [4]
References
Ref 1 Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur J Biochem. 2002 Dec;269(24):6037-41. doi: 10.1046/j.1432-1033.2002.03294.x.
Ref 2 Molecular cloning of a novel putative potassium channel-blocking neurotoxin from the venom of the North African scorpion, Androctonus amoreuxi. Peptides. 2005 May;26(5):731-6. doi: 10.1016/j.peptides.2004.12.002. Epub 2005 Jan 11.
Ref 3 Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom. Biochim Biophys Acta. 2000 Sep 29;1468(1-2):203-12. doi: 10.1016/s0005-2736(00)00259-5.
Ref 4 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
Ref 5 BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochem J. 2004 Mar 15;378(Pt 3):745-52. doi: 10.1042/BJ20031324.
Ref 6 A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and localization in rat brain. FEBS Lett. 2001 Jul 13;501(1):31-6. doi: 10.1016/s0014-5793(01)02620-5.
Ref 7 Kv4 channels sensitive to BmTX3 in rat nervous system: autoradiographic analysis of their distribution during brain ontogenesis. Eur J Neurosci. 2006 Sep;24(5):1325-40. doi: 10.1111/j.1460-9568.2006.05020.x.
Ref 8 Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. 2013 May 15;591(10):2419-27. doi: 10.1113/jphysiol.2012.248831. Epub 2013 Feb 25.
Ref 9 Functional consequences of deleting the two C-terminal residues of the scorpion toxin BmTX3. Biochim Biophys Acta. 2003 Mar 21;1646(1-2):152-6. doi: 10.1016/s1570-9639(02)00557-5.
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