Peptide Information

General Information of This Peptide
Peptide ID
BTDP008373
Peptide Name
Kappa-actitoxin-Aer3a
Symonym
AnerK; Potassium channel toxin AETX K
Species
Anemonia erythraea (Sea anemone)
Uniprot Name
K1A_ANEER
Alphafold ID
Q0EAE5
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 7OD2
Sequence
MKGQMIICLVLIALCMSVVVMAQNLRAEELEKANPKDERVRSFERNQKRACKDYLPKSEC
TQFRCRTSMKYKYTNCKKTCGTC
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Sequence Length
83
Mass (Da)
9663
Signal Sequence
MKGQMIICLVLIALCMSVVVMA
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Sequence Removed Signal Peptide
QNLRAEELEKANPKDERVRSFERNQKRACKDYLPKSECTQFRCRTSMKYKYTNCKKTCGT
C
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Disulfide Bond
51-83;60-76;65-80
PDB ID
7OD2
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anemonia
Species: Anemonia erythraea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker-KcsA Inhibition constant
0.3 nM
 .
Blocker
 [1]
 Target Info    Shaker Inhibition constant
445 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition constant
1.23 μM
 .
Blocker
 [1]
 Target Info    Kv1.2 Inhibition constant
2.243 μM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
91 nM
 .
Blocker
 [2], [3]
 Target Info    synaptosomal membrane IC50
91 nM
 .
Block the binding of dendrotoxin to rat synaptosomal membrane in a dose-dependent manner
 [2], [3]
References
Ref 1 Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E7013-21. doi: 10.1073/pnas.1514728112. Epub 2015 Dec 1.
Ref 2 Isolation and cDNA cloning of a potassium channel peptide toxin from the sea anemone Anemonia erythraea. Toxicon. 2006 Oct;48(5):536-42. doi: 10.1016/j.toxicon.2006.07.002. Epub 2006 Jul 7.
Ref 3 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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