Target Information

General Information of This Target
Target ID
BTDT10257
Target Name
Sodium channel protein type 10 subunit alpha
Target Bioclass
Transporter and channel
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N.A.
Species: Mammalian
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    NU-buthitoxin-Ptr1a Effect . [1]
 Toxin Info    NU-theraphotoxin-Preg1a Effect . [1]
 Toxin Info    Mu-conotoxin TsIIIA IC50
2.11 μM
 [2], [3], [4]
References
Ref 1 A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16.
Ref 2 Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon. 2013 Dec 15;76:150-9. doi: 10.1016/j.toxicon.2013.09.020. Epub 2013 Sep 27.
Ref 3 A novel -conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents. Toxicon. 2017 May;130:11-18. doi: 10.1016/j.toxicon.2017.02.013. Epub 2017 Feb 17.
Ref 4 -conotoxin TsIIIA, a peptide inhibitor of human voltage-gated sodium channel hNa(v)1.8. Toxicon. 2020 Oct 30;186:29-34. doi: 10.1016/j.toxicon.2020.07.024. Epub 2020 Aug 3.
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