Target Information

General Information of This Target
Target ID
BTDT10298
Target Name
Voltage-dependent R-type calcium channel subunit alpha-1E
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Omega-theraphotoxin-Pm1a Inhibition rate . [1], [2]
 Toxin Info    Omega-filistatoxin-Kh1a IC50
96.4 nM
 [3]
References
Ref 1 Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function. Cell Mol Life Sci. 2010 Aug;67(16):2799-813. doi: 10.1007/s00018-010-0359-x. Epub 2010 Apr 6.
Ref 2 Isolation, synthesis and characterization of -TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels. Biochem Pharmacol. 2014 May 15;89(2):276-86. doi: 10.1016/j.bcp.2014.02.008. Epub 2014 Feb 19.
Ref 3 Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW13.3. Mol Pharmacol. 1998 Aug;54(2):407-18. doi: 10.1124/mol.54.2.407.
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