Target Information

General Information of This Target
Target ID
BTDT10291
Target Name
Vasopressin V2 receptor
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conopressin-S Effect . [1], [2]
 Toxin Info    Conopressin/conophysin, isoform 3 Effective concentration 50
44.06 nM
 [3]
 Toxin Info    Conopressin/conophysin, isoform 3 Effective concentration 50
299.2 nM
 [3]
 Toxin Info    Conopressin/conophysin, isoform 3 Effective concentration 50
299.2 nM
 [3]
 Toxin Info    Mambaquaretin-7 IC50
58 nM
 [4], [5]
References
Ref 1 Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms. J Biol Chem. 1987 Nov 25;262(33):15821-4.
Ref 2 Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J Biol Chem. 2008 Mar 14;283(11):7100-8. doi: 10.1074/jbc.M706477200. Epub 2008 Jan 2.
Ref 3 Cone snail analogs of the pituitary hormones oxytocin/vasopressin and their carrier protein neurophysin. Proteomic and transcriptomic identification of conopressins and conophysins. Biochim Biophys Acta Proteins Proteom. 2020 May;1868(5):140391. doi: 10.1016/j.bbapap.2020.140391. Epub 2020 Feb 10.
Ref 4 The amino acid sequence of a weak trypsin inhibitor B from Dendroaspis Polylepis polylepis (black mamba) venom. Hoppe Seylers Z Physiol Chem. 1981 Oct;362(10):1377-84. doi: 10.1515/bchm2.1981.362.2.1377.
Ref 5 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28.
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