Peptide Information

General Information of This Peptide
Peptide ID
BTDP003998
Peptide Name
Conopressin-S
Symonym
Arg-conopressin S
Species
Conus striatus (Striated cone)
Uniprot Name
CONO_CONST
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
CIIRNCPRG
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Sequence Length
9
Mass (Da)
1031
Sequence Removed Signal Peptide
CIIRNCPRG
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Disulfide Bond
16
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    vasopressin V1b receptor (AVPR1B) Inhibition constant
8.3 nM
 . . [1], [2]
 Target Info    oxytocin receptor (OXTR) Inhibition constant
175 nM
 . . [1], [2]
 Target Info    V1a receptor (AVPR1A) Inhibition constant
827 nM
 . . [1], [2]
 Target Info    V1a2R Effect .
10 μM
 . [1], [2]
References
Ref 1 Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms. J Biol Chem. 1987 Nov 25;262(33):15821-4.
Ref 2 Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J Biol Chem. 2008 Mar 14;283(11):7100-8. doi: 10.1074/jbc.M706477200. Epub 2008 Jan 2.
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