Peptide Information

General Information of This Peptide
Peptide ID
BTDP001741
Peptide Name
Conopressin/conophysin, isoform 3
Symonym
isoform 3
Species
Conus monile (Necklace cone)
Uniprot Name
CESS3_CONMO
Alphafold ID
A0A4Y5X1A7
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: A0A4Y5X1A7
Sequence
ACFIRNCPKGGKRNVDEGPTKPCMFCSFGQCVAPHTCCGEKGCEMGTVDANMCQEENESP
IPCHVFGKRCLLNHPGNSHGNCVTYGICCSHDTCTVHLACM
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Sequence Length
101
Mass (Da)
10873
Sequence Removed Signal Peptide
ACFIRNCPKGGKRNVDEGPTKPCMFCSFGQCVAPHTCCGEKGCEMGTVDANMCQEENESP
IPCHVFGKRCLLNHPGNSHGNCVTYGICCSHDTCTVHLACM
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Disulfide Bond
2-7;23-63;26-37;31-53;38-43;70-88;82-100;89-94
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus monile
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    V1aR Effective concentration 50
10.6 nM
 . . [1]
 Target Info    V1a2R Effective concentration 50
44.06 nM
 . . [1]
 Target Info    vasopressin V1b receptor (AVPR1B) Effective concentration 50
51.92 nM
 . . [1]
 Target Info    V1aR Effective concentration 50
123.78 nM
 . . [1]
 Target Info    V1a2R Effective concentration 50
299.2 nM
 . . [1]
 Target Info    V1a2R Effective concentration 50
299.2 nM
 . . [1]
 Target Info    oxytocin receptor (OXTR) Effective concentration 50
353.73 nM
 . . [1]
 Target Info    oxytocin receptor (OXTR) Effective concentration 50
455.66 nM
 . . [1]
References
Ref 1 Cone snail analogs of the pituitary hormones oxytocin/vasopressin and their carrier protein neurophysin. Proteomic and transcriptomic identification of conopressins and conophysins. Biochim Biophys Acta Proteins Proteom. 2020 May;1868(5):140391. doi: 10.1016/j.bbapap.2020.140391. Epub 2020 Feb 10.
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