Peptide Information

General Information of This Peptide
Peptide ID
BTDP003640
Peptide Name
Mu-conotoxin TsIIIA
Species
Conus tessulatus (Tessellate cone)
Uniprot Name
CM3A_CONTS
Alphafold ID
H2BKS9
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: H2BKS9
Sequence
MMSKLGVLLTICLLLFPLTAVPLDGDQPADQPAERKQNEQHPLFDQKRGCCRWPCPSRCG
MARCCSS
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Sequence Length
67
Mass (Da)
7463
Signal Sequence
MMSKLGVLLTICLLLFPLTA
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Sequence Removed Signal Peptide
VPLDGDQPADQPAERKQNEQHPLFDQKRGCCRWPCPSRCGMARCCSS
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Disulfide Bond
50-59;51-64;55-65
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus tessulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 IC50
2.11 μM
 . . [1], [2], [3]
References
Ref 1 Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon. 2013 Dec 15;76:150-9. doi: 10.1016/j.toxicon.2013.09.020. Epub 2013 Sep 27.
Ref 2 A novel -conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents. Toxicon. 2017 May;130:11-18. doi: 10.1016/j.toxicon.2017.02.013. Epub 2017 Feb 17.
Ref 3 -conotoxin TsIIIA, a peptide inhibitor of human voltage-gated sodium channel hNa(v)1.8. Toxicon. 2020 Oct 30;186:29-34. doi: 10.1016/j.toxicon.2020.07.024. Epub 2020 Aug 3.
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