Peptide Information

General Information of This Peptide
Peptide ID
BTDP008465
Peptide Name
Potassium channel toxin alpha-KTx 15.1
Symonym
Peptide Aa1
Species
Androctonus australis (Sahara scorpion)
Uniprot Name
KA151_ANDAU
Alphafold ID
P60233
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P60233
Sequence
QNETNKKCQGGSCASVCRRVIGVAAGKCINGRCVCYP
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Sequence Length
37
Mass (Da)
3875
Sequence Removed Signal Peptide
QNETNKKCQGGSCASVCRRVIGVAAGKCINGRCVCYP
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Disulfide Bond
8-28;13-33;17-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus australis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv4 Inhibition constant
0.044 nM
 .
Blocker
 [1], [2]
 Target Info    Kv4 Inhibition constant
150 nM
 .
Blocker
 [1], [2]
 Target Info    Kv11 Inhibition rate
25 %
600 nM
Blocker
 [2]
 Target Info    Kv Inhibition rate
25 %
600 nM
 . [1], [2]
 Target Info    Shaker IC50
4.5 μM
 .
Blocker
 [3]
References
Ref 1 Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom. Biochim Biophys Acta. 2000 Sep 29;1468(1-2):203-12. doi: 10.1016/s0005-2736(00)00259-5.
Ref 2 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
Ref 3 A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes. Biochem Biophys Res Commun. 1998 Jan 14;242(2):287-91. doi: 10.1006/bbrc.1997.7929.
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