Peptide Information

General Information of This Peptide
Peptide ID
BTDP008469
Peptide Name
Potassium channel toxin alpha-KTx 15.7
Symonym
Neurotoxin AamTX
Species
Androctonus amoreuxi (African fattail scorpion) (Scorpio amoreuxi)
Uniprot Name
KA157_ANDAM
Alphafold ID
Q5K0E0
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q5K0E0
Sequence
MKFSSIILLTLLICSMSIFGNGQVQTNKKCKGGSCASVCAKEIGVAAGKCINGRCVCYP
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Sequence Length
59
Mass (Da)
6146
Signal Sequence
MKFSSIILLTLLICSMSIFGNG
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Sequence Removed Signal Peptide
QVQTNKKCKGGSCASVCAKEIGVAAGKCINGRCVCYP
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Disulfide Bond
30-50;35-55;39-57
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus amoreuxi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv4 Inhibition constant
0.02 nM
 .
Blocker
 [1]
 Target Info    Kv4 Inhibition constant
131 nM
 .
Blocker
 [1]
 Target Info    Kv11 IC50
7.9 μM
 .
Blocker
 [2]
References
Ref 1 Molecular cloning of a novel putative potassium channel-blocking neurotoxin from the venom of the North African scorpion, Androctonus amoreuxi. Peptides. 2005 May;26(5):731-6. doi: 10.1016/j.peptides.2004.12.002. Epub 2005 Jan 11.
Ref 2 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
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