Target Information

General Information of This Target
Target ID
BTDT10081
Target Name
Muscarinic acetylcholine receptor M2
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Muscarinic toxin alpha Inhibition constant
44 nM
 [1- 5]
 Toxin Info    Adrenergic toxin rho-elapitoxin-Dp1b Inhibition constant
17.78279 μM
 [6], [7]
 Toxin Info    Dendroaspis polylepis MT9 Ki/Kd
120 - 399 nM
 [8]
References
Ref 1 Muscarinic toxins from the black mamba Dendroaspis polylepis. Eur J Biochem. 1995 Dec 1;234(2):579-85. doi: 10.1111/j.1432-1033.1995.579_b.x.
Ref 2 Kinetic evidence for different mechanisms of interaction of black mamba toxins MT alpha and MT beta with muscarinic receptors. Toxicon. 2001 Feb-Mar;39(2-3):377-82. doi: 10.1016/s0041-0101(00)00141-0.
Ref 3 The three-finger toxin MTalpha is a selective alpha(2B)-adrenoceptor antagonist. Toxicon. 2010 Sep 1;56(3):440-7. doi: 10.1016/j.toxicon.2010.05.001. Epub 2010 May 11.
Ref 4 Adrenoceptor activity of muscarinic toxins identified from mamba venoms. Br J Pharmacol. 2011 Sep;164(2b):538-50. doi: 10.1111/j.1476-5381.2011.01468.x.
Ref 5 Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.
Ref 6 The amino acid sequence of protein CM-3 from Dendroaspis polylepis polylepis (black mamba) venom. Int J Biochem. 1985;17(6):695-9. doi: 10.1016/0020-711x(85)90367-2.
Ref 7 New -adrenergic property for synthetic MT and CM-3 three-finger fold toxins from black mamba. Toxicon. 2013 Dec 1;75:160-7. doi: 10.1016/j.toxicon.2013.04.017. Epub 2013 May 3.
Ref 8 MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries. Biomed Pharmacother. 2022 Jun;150:113094. doi: 10.1016/j.biopha.2022.113094. Epub 2022 May 10.
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