Peptide Information

General Information of This Peptide
Peptide ID
BTDP006368
Peptide Name
Muscarinic toxin alpha
Symonym
MT-alpha
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
3SIMA_DENPO
Alphafold ID
P80494
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 7ULS
Sequence
LTCVTSKSIFGITTENCPDGQNLCFKKWYYLNHRYSDITWGCAATCPKPTNVRETIHCCE
TDKCNE
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Sequence Length
66
Mass (Da)
7554
Sequence Removed Signal Peptide
LTCVTSKSIFGITTENCPDGQNLCFKKWYYLNHRYSDITWGCAATCPKPTNVRETIHCCE
TDKCNE
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Disulfide Bond
3-24;17-42;46-58;59-64
PDB ID
7ULS
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    CHRM3 Inhibition constant
3 nM
 . . [1- 5]
 Target Info    CHRM4 Inhibition constant
5 nM
 . . [1- 5]
 Target Info    CHRM5 Inhibition constant
8 nM
 . . [1- 5]
 Target Info    muscarinic acetylcholine receptor M1 Inhibition constant
23 nM
 . . [1- 5]
 Target Info    type 2 receptor (CHRM2) subtype Inhibition constant
44 nM
 . . [1- 5]
References
Ref 1 Muscarinic toxins from the black mamba Dendroaspis polylepis. Eur J Biochem. 1995 Dec 1;234(2):579-85. doi: 10.1111/j.1432-1033.1995.579_b.x.
Ref 2 Kinetic evidence for different mechanisms of interaction of black mamba toxins MT alpha and MT beta with muscarinic receptors. Toxicon. 2001 Feb-Mar;39(2-3):377-82. doi: 10.1016/s0041-0101(00)00141-0.
Ref 3 The three-finger toxin MTalpha is a selective alpha(2B)-adrenoceptor antagonist. Toxicon. 2010 Sep 1;56(3):440-7. doi: 10.1016/j.toxicon.2010.05.001. Epub 2010 May 11.
Ref 4 Adrenoceptor activity of muscarinic toxins identified from mamba venoms. Br J Pharmacol. 2011 Sep;164(2b):538-50. doi: 10.1111/j.1476-5381.2011.01468.x.
Ref 5 Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.
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