Peptide Information

General Information of This Peptide
Peptide ID
BTDP001737
Peptide Name
Dendroaspis polylepis MT9
Symonym
Three-finger toxin
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
3SX9_DENPO
Alphafold ID
A0A4P1LYC9
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6R5M
Sequence
TICHIQISKTHGILKTCEENSCYKMSVRGWIIGRGCGCPSAVRPRQVQCCTSDKCNY
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Sequence Length
57
Mass (Da)
6364
Sequence Removed Signal Peptide
TICHIQISKTHGILKTCEENSCYKMSVRGWIIGRGCGCPSAVRPRQVQCCTSDKCNY
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Disulfide Bond
3-22;17-36;38-49;50-55
PDB ID
6R5M
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    type 2 receptor (CHRM2) subtype Ki/Kd
120 - 399 nM
 .
Antagonist
[1]
 Target Info    muscarinic acetylcholine receptor M1 Inhibition rate .
100 μM
Antagonist
[1]
 Target Info    CHRM3 Inhibition rate .
100 μM
Antagonist
[1]
 Target Info    CHRM4 Inhibition rate .
100 μM
Antagonist
[1]
 Target Info    CHRM5 Inhibition rate .
100 μM
Antagonist
[1]
References
Ref 1 MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries. Biomed Pharmacother. 2022 Jun;150:113094. doi: 10.1016/j.biopha.2022.113094. Epub 2022 May 10.
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