Peptide Information

General Information of This Peptide
Peptide ID
BTDP005878
Peptide Name
Adrenergic toxin rho-elapitoxin-Dp1b
Symonym
Muscarinic toxin CM-3; Protein CM-3
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
3SI3_DENPO
Alphafold ID
P25518
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P25518
Sequence
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDITRGCVATCPIPENYDSIHCCKT
EKCNN
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Sequence Length
65
Mass (Da)
7344
Sequence Removed Signal Peptide
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDITRGCVATCPIPENYDSIHCCKT
EKCNN
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Disulfide Bond
3-24;17-42;46-57;58-63
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    alpha-1A adrenergic receptor (ADRA1A) Inhibition constant
0.37 nM
 . . [1], [2]
 Target Info    ADRA1B Inhibition constant
10.47 nM
 . . [1], [2]
 Target Info    ADRA1D Inhibition constant
104.71 nM
 . . [1], [2]
 Target Info    ADRA2C Inhibition constant
165.96 nM
 . . [1], [2]
 Target Info    muscarinic acetylcholine receptor M1 Inhibition constant
4.46684 μM
 . . [1], [2]
 Target Info    type 2 receptor (CHRM2) subtype Inhibition constant
17.78279 μM
 . . [1], [2]
References
Ref 1 The amino acid sequence of protein CM-3 from Dendroaspis polylepis polylepis (black mamba) venom. Int J Biochem. 1985;17(6):695-9. doi: 10.1016/0020-711x(85)90367-2.
Ref 2 New -adrenergic property for synthetic MT and CM-3 three-finger fold toxins from black mamba. Toxicon. 2013 Dec 1;75:160-7. doi: 10.1016/j.toxicon.2013.04.017. Epub 2013 May 3.
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